External control of the Drosophila melanogaster egg to imago development period by specific combinations of 3D low-frequency electric and magnetic fields

We report that the duration of the egg-to-imago development period of the Drosophila melanogaster, and the imago longevity, are both controllable by combinations of external 3-dimensional (3D) low-frequency electric and magnetic fields (LFEMFs). Both these periods may be reduced or increased by applying an appropriate configuration of external 3D LFEMFs. We report that the longevity of D. melanogaster imagoes correlates with the duration of the egg-to-imago development period of the respective eggs. We infer that metabolic processes in both eggs and imago are either accelerated (resulting in reduced time periods) or slowed down (resulting in increased time periods). We propose that external 3D LFEMFs induce electric currents in live systems as well as mechanical vibrations on sub-cell, whole-cell and cell-group levels. These external fields induce media polarization due to ionic motion and orientation of electric dipoles that could moderate the observed effects. We found that the longevity of D. melanogaster imagoes is affected by action of 3D LFEMFs on the respective eggs in the embryonic development period (EDP). We interpret this effect as resulting from changes in the regulation mechanism of metabolic processes in D. melanogaster eggs, inherited by the resulting imagoes. We also tested separate effects of either 3D electric or 3D magnetic fields, which were significantly weaker

Evaluation of quality parameters of apple juices using near-infrared spectroscopy and chemometrics

Near-infrared (NIR) spectra were recorded for commercial apple juices. Analysis of these spectra using partial least squares (PLS) regression revealed quantitative relations between the spectra and quality- and taste-related properties of juices: soluble solids content (SSC), titratable acidity (TA), and the ratio of soluble solids content to titratable acidity (SSC/TA). Various spectral preprocessing methods were used for model optimization. The optimal spectral variables were chosen using the jack-knife-based method and different variants of the interval PLS (iPLS) method. The models were cross-validated and evaluated based on the determination coefficients (R-2), root-mean-square error of cross-validation (RMSECV), and relative error (RE). The best model for the prediction of SSC (R-2 = 0.881, RMSECV = 0.277 degrees Brix, and RE = 2.37%) was obtained for the first-derivative preprocessed spectra and jack-knife variable selection. The optimal model for TA (R-2 = 0.761, RMSECV = 0.239 g/L, and RE = 4.55%) was obtained for smoothed spectra in the range of 6224-5350 cm(-1). The best model for the SSC/TA (R-2 = 0.843, RMSECV = 0.113, and RE = 5.04%) was obtained for the spectra without preprocessing in the range of 6224-5350 cm(-1). The present results show the potential of the NIR spectroscopy for screening the important quality parameters of apple juices.National Science Centre, Poland [2016/23/B/NZ9/03591

Education today: 12 + 5 < 4 - lessons of education reforms in Portugal and beyond

Since the adoption of the ‘Lei de Bases…’ of 1984, the quality of education in Portugal is declining, undermined by ‘critical, creative and independent thinking’, implemented by neglecting memorization as a learning tool, as supposedly students should understand things without knowing them. As a consequence, vast majority of students can’t retain any abstract knowledge. They prepare from scratch for their tests and forget everything afterwards. The students never acquire essential primary-school skills such as capacity to do mental calculations, hence the title of this report, comparing contemporary school + university education to pre-1984 primary school of 4 years. The quality of education is further degraded by ‘evaluation’ of teachers at school and university, judged by academic success and degree of satisfaction of their students. With the students objectively incapable to learn, understand or remember, the teachers have a dilemma of either letting such students pass without retained knowledge, skills and competences, or else have their own ‘evaluation’ suffer. As the generations change, students who were ‘passed’ become teachers themselves, still with no retained knowledge and thus no moral authority to fail their own students. Thus, the level of requirements monotonously degrades, with the educational fraud perpetuated in the new generations.info:eu-repo/semantics/publishedVersio

Knowledge-based economy

The European Union is resorting to long-term multi-annual political and economical plans. The current set of plans, “Horizons 2020”, also involves restructuring the educational system, as in the Bologna system. The idea behind it is that education should help industry to win the competitive battle with other major economical blocks. The idea is best described by the adage of the European Union of developing a so-called “knowledge-based economy”. It implies that education is a form of investment. We should educate people – the society should spend effort on educating people – in order for society to make profit on it. Contrasting this is the idea of education as a consumption good. In the latter, people study to become knowledgeable, since knowledge makes a person happy. We discuss here the dissident view why an educational system that is for investment-only will at the end not bear fruit and will destroy science, creativity and eventually any form of competitiveness in the economy. It will lead to moral as well as financial bankruptcy.info:eu-repo/semantics/publishedVersio

Computational modeling of In vitro swelling of mitochondria: A biophysical approach

Swelling of mitochondria plays an important role in the pathogenesis of human diseases by stimulating mitochondria-mediated cell death through apoptosis, necrosis, and autophagy. Changes in the permeability of the inner mitochondrial membrane (IMM) of ions and other substances induce an increase in the colloid osmotic pressure, leading to matrix swelling. Modeling of mitochondrial swelling is important for simulation and prediction of in vivo events in the cell during oxidative and energy stress. In the present study, we developed a computational model that describes the mechanism of mitochondrial swelling based on osmosis, the rigidity of the IMM, and dynamics of ionic/neutral species. The model describes a new biophysical approach to swelling dynamics, where osmotic pressure created in the matrix is compensated for by the rigidity of the IMM, i.e., osmotic pressure induces membrane deformation, which compensates for the osmotic pressure effect. Thus, the effect is linear and reversible at small membrane deformations, allowing the membrane to restore its normal form. On the other hand, the membrane rigidity drops to zero at large deformations, and the swelling becomes irreversible. As a result, an increased number of dysfunctional mitochondria can activate mitophagy and initiate cell death. Numerical modeling analysis produced results that reasonably describe the experimental data reported earlier.National Institute of General Medical Sciences of the National Institutes of Health [SC1GM128210]; Puerto Rico Institute for Functional Nanomaterials (National Science Foundation Grant) [1002410]; National Aeronautics and Space Administration (NASA) Puerto Rico Established Program to Stimulate Competitive Research (EPSCoR) [NNX15AK43A